Brigham and Women's Hospital | Main / Lucila Ohno-Machado, MD, PhD

Lucila Ohno-Machado, MD, PhD

Professor of Medicine
Chief, Division of Biomedical Informatics
University of California San Diego
Director, Biomedical Research Informatics for Global Health Program
Associate Editor, Journal of the American Medical Informatics Association

Fellow, American College of Medical Informatics
Fellow, American Institute for Medical and Biological Engineering

Education

PhD, Medical Information Sciences and Computer Science, Stanford University
MD, University of São Paulo

Research Projects

SMART, Scalable Medical Alert Response Technology
Validation of Breast Cancer Biomarkers
Assessing the Quality of Individual Estimates in Decision Support Systems

Collaborations

Selected Publications

(see also PubMed)

Matheny ME, Morrow DA, Ohno-Machado L, Cannon CP, Sabatine MS, Resnic FS. Validation of an Automated Safety Surveillance System with Prospective, Randomized Trial Data. Med Decis Making. 2008 Dec 2.

Fu S, Zhao H, Shi J, Abzhanov A, Crawford K, Ohno-Machado L, Zhou J, Du Y, Kuo WP, Zhang J, Jiang M, Jin JG. Peripheral arterial occlusive disease: global gene expression analyses suggest a major role for immune and inflammatory responses. BMC Genomics. 2008 Aug 1;9:369.

Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, van de Wiel MA, Hovig E, Lyng H. Validation of oligoarrays for quantitative exploration of the transcriptome. BMC Genomics. 2008 May 30;9(1):258. (full text) (pdf)

Hasina R, Whipple ME, Martin LE, Kuo WP, Ohno-Machado L, Lingen MW. Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications. Lab Invest. 2008 Apr;88(4):342-53.

Matheny ME, Ohno-Machado L, Resnic FS. Risk-Adjusted SPRT Control Chart Methods for Monitoring Operator and Institutional Mortality Rates in Interventional Cardiology. American Heart Journal. 2008 Jan;155(1):114-20.

Curtis DW, Pino EJ, Bailey JM, Shih EI, Waterman J, Vinterbo SA, Stair TO, Gutagg JV, Greenes RA, Ohno-Machado L. SMART: An Integrated, Wireless System for Monitoring Unattended Patients. J Am Med Inform Assoc. 2007;15(1):44-53.

Stransky B, Barrera J, Ohno-Machado L, De Souza SJ. Modeling cancer: integration of "omics" information in dynamic systems. J Bioinform Comput Biol. 2007 Aug;5(4):977-86.

Matheny ME, Resnic FS, Ohno-Machado L. Effects of SVM parameter optimization on discrimination and calibration for post-procedural PCI mortality. J Biomed Inform. 2007 May 18.

Liu F, Jenssen TK, Trimarchi J, Punzo C, Cepko CL, Ohno-Machado L, Hovig E, Kuo WP. Comparison of Hybridization-based and Sequencing-based Gene Expression Technologies on Biological Replicates. BMC Genomics. 2007;8:153. (full text) (pdf)

Galante PAF, Trimarchi J, Cepko C, de Souza SJ, Ohno-Machado L, Kuo WP. Automatic Correspondence of Tags and Genes (ACTG): A Tool for the Analysis of SAGE, MPSS, and SBS Data. Bioinformatics. 2007;(Feb 3). (full text) (pdf)

Ohno-Machado L, Resnic FS, Matheny ME. Prognosis in Critical Care. Annual Review of Biomedical Engineering. 2006;8:567-599.

Kuo WP, Liu F, Trimarchi J, et al. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006;24(7):832-840.

Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA. Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology. 2006;239(2):506-13. (full text) (pdf)

Matheny ME, Ohno-Machado L, Resnic FS. Monitoring device safety in interventional cardiology. J Am Med Inform Assoc. 2006;13(2):180-7. (full text) (pdf)

Weber G, Ohno-Machado L, Shieber S. Representation in stochastic search for phylogenetic tree reconstruction. J Biomed Inform. 2006;39(1):43-50.

Vinterbo SA, Dreiseitl S, Ohno-Machado L. Approximation properties of haplotype tagging. BMC Bioinformatics. 2006;7 :8. (full text) (pdf)

Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L. The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform. 2005;38(5):404-15.

Zou KH, Resnic FS, Talos IF, Goldberg-Zimring D, Bhagwat JG, Haker SJ, Kikinis R, Jolesz FA, Ohno-Machado L. A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method. J Biomed Inform. 2005;38(5):395-403.

Matheny ME, Ohno-Machado L, Resnic FS. Discrimination and calibration of mortality risk prediction models in interventional cardiology. J Biomed Inform. 2005;38(5):367-75.

Vinterbo SA, Kim EY, Ohno-Machado L. Small, fuzzy and interpretable gene expression based classifiers. Bioinformatics. 2005;21(9):1964-70.

Carrino JA, Ohno-Machado L. Development of radiology prediction models using feature analysis. Acad Radiol. 2005;12(4):415-21.